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Research Projects

A curated list of my work in emerging pathogen serology, diagnostics, and public health.

Mpox Immunity
Immunology & Virology

The 2022 mpox outbreak highlighted gaps in our understanding of orthopoxvirus immunity. This research characterizes the immune responses following both natural mpox infection and historic smallpox vaccination.

Key Findings

  • Comparable antibody responses between mpox-infected and smallpox-vaccinated individuals.
  • Identification of immunodominant antigens for diagnostic development.
Key Paper: Otter et al. (2023), Nature Communications.
Molecular Serology
Next-Gen Methods

Utilizing phage display and next-generation sequencing to map antibody-antigen interactions at epitope resolution.

Applications

  • Vaccine design optimization.
  • Diagnostic antigen selection.
  • Understanding immune escape.
COVID-19 Serology
Public Health Surveillance

Led implementation of SARS-CoV-2 serology testing at national scale, processing over 1.3 million samples.

Impact

  • Data used for JCVI policy decisions.
  • National modeling and forecasting.
  • Vaccine effectiveness studies.
H5N1 Serosurveillance
Risk Assessment

Assessment of H5N1 avian influenza exposure in at-risk populations using national blood donor samples.

Determining the risk of H5N1 spillover in at-risk areas at a population-level.